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Diana Katsman

Diana Katsman, M.D. PHD

Vitreoretinal Specialist

Education

  • BS University of California, Los Angeles, 09/2001 Molecular Biology/Russian Literature
  • M.D. University of California, Irvine, 06/2008
  • Internship Harbor-UCLA Medical Center, Los Angeles, CA, 07/2008-06/2009 Internal Medicine (PGY-1)
  • Ph.D. University of California, Los Angeles, 06/2012
  • EyeSTAR Resident, Jules Stein Eye Institute, UCLA, 07/2009-06/2012 Residency Ophthalmology, Jules Stein Eye Institute, UCLA, 07/2012-06/2016 Fellowship Vitreo-Retinal Disease and Surgery, Loma Linda University 07/2016-07/2018

Licensure

  • Medical Board of California:  License # A112485 07/2009-Present

Professional experience

  • 08/2018-Present Retina Institute of California, Vitreo-Retinal Surgeon, Los Angeles, CA 07/2016
  • 07/2018 Fellowship, Vitreo-Retinal Disease and Surgery, Loma Linda University
  • 07/2012-06/2016 Residency, Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles,
    CA
  • 07/2009-06/2012 EyeSTAR (Specialty Training in Advanced Research) Ophthalmology Resident, Jules Stein Eye Institute, UCLA, Los Angeles, CA
  • 07/2008-06/2009 Internship, Internal Medicine, Harbor-UCLA Medical Center, Los Angeles, CA
  • 07/2004-06/2006 Howard Hughes Medical Student Research Fellow, Department of Neurology, UCLA
  • 2002-Summer American Heart Association Research Fellow, Department of Neurology, UCLA
  • 09/2001-08/2002 Research Associate, Department of Neurology, UCLA 09/1999-09/2001 Research Associate, Department of Neurobiology, UCLA
  • 1999 Summer Research Associate, Department of Head and Neck Surgery, UCLA
  • 07/1998-06/1999 Research Associate, Department of Molecular Biology, UCLA

Honors and special awards

  • 2012 ARVO AFER/Santern Inc. Travel Grant Recipient
  • 2012 ARVO Hot Topic Award: Translational Research: Seeing the Possibilities
  • 2010 BSCRC-CIRM Training Grant Fellowship Award
  • 2009 BSCRC-CIRM Training Grant Fellowship Award
  • 2009 Hope for Vision New Investigator Award
  • 2008 Distinction in Research, UCI School of Medicine
  • 2007 Honors Notation: Medicine Sub Internship, UCI School of Medicine
  • 2007 Honors Notation: Pediatric Radiology Clerkship, UCLA School of Medicine
  • 2007 Honors Notation: Surgery Clerkship, UCI School of Medicine
  • 2007 Honors Notation: Ophthalmology Section, UCI School of Medicine
  • 2005 Howard Hughes Medical Student Training Fellowship Continued Research Support Award
  • 2005 9th International Conference on Neural Transplantation and Repair Frontiers in Research Abstract Award
  • 2005 9th International Conference on Neural Transplantation and Repair Travel Grant
  • 2004 Recipient of the Howard Hughes Medical Student Training Fellowship
  • 2003 American Heart Association Medical Student Summer Research Fellowship
  • 2003 Honors Notation: Medical Neurobiology, UCI College of Medicine
  • 2003 Honors Notation: Medical Immunology, UCI College of Medicine
  • 2003 Honors Notation: Medical Genetics, UCI College of Medicine
  • 2002 Cum Laude, UCLA
  • 2002 Departmental Honors: UCLA Department of Molecular Cell Biology
  • 2001 Honors Award in Scientific Technical Writing
  • 2001 Golden Key International Honor Society
  • 1999-2002 Dean’s Honors List

Research grants and fellowships received

  • American Heart Association Medical Student Research Fellowship (2003) Investigation of molecular correlates of axonal sprouting after cerebral ischemia in the periinfarct cortex.
  • Howard Hughes Medical student Research Fellowship (2004)
  • Howard Hughes Medical Student Research Fellowship Additional Year of Research (2005) Investigating the genetic profile of regenerating neurons after stroke within the peri-infarct cortex.
  • Hope for Vision New Investigator Award (2009)
    Investigating the geetic profile of Embryonic Stem Cell-Derived Microvesicles, and their ability to modify gene expression of Muller cells of the retina.
  • BSCRC-CIRM Training Grant Fellowship (2009)
  • BSCRC-CIRM Training Grant Fellowship Continued Support (2010)
    Investigating the potential role of Embryonic Stem Cell-Derived Microvesicles to activate retinal regenerative program in Muller cells of the retina.
  • NIH-LRP Clinical Research Award (2010-2012)
    Investigating the potential role of Embryonic Stem Cell-Derived Microvesicles to activate retinal regenerative program in Muller cells of the retina in in-vitro and in-vivo studies.

Clinical Research Participation:

  • CEDAR, Allergan: Investigator
    Safety and Efficacy of Abicipar Pegol (AGN0150998) in Patients with Neovascular Age-Related Macular Degeneration
  • QUARK NAION: Investigator
    A Phase 2/3, Randomized, Double-Masked Sham-Controlled Trial of QPI-1007 Delivered by Single Or Multi-Dose Intravitreal Injection(s) to Subjects with Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
  • ALCAN HAWK: Investigator
    A Two-Year, Randomized, Double-Masked, Multicenter, Three-ARM Study Comparing the Efficacy and Safety of RTH258 versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration

Professional associations

  • 2009-Present Member, American Academy of Ophthalmology
  • 2005-Present Member, Society for Neuroscience
  • 2002-Present Member, American College of Physicians
  • 2002-Present Member, National Association of Doctors
  • 2002-Present Member, California Medical Association
  • 2002-Present Member, American Medical Association

Mentorship

  • 2010-2012 Mentored two undergraduate independent researchers on a project that resulted in multiple abstract presentations and a peer reviewed publication

Lecturer

  • 03-08/2012 Continuing nursing education lecture series: Eye diseases commonly encountered in skilled nursing facilities. Country Villa Health Services, Culver City, CA

Peer reviewed publications

  • D. Katsman, J.T. Fan, J. Deisch, M. Henao. Retinal detachment in a syphilitic patient: a masquerade syndrome. Retinal Cases and Brief Reports. Manuscript Submitted 2017
  • D. Katsman, C. Sanfilippo, D.S. Sarraf. Panretinal degeneration associated with long-term hydroxychloroquine use and heterozygous USH2A mutation. Retinal Cases and Brief Reports (11):S77-S80. 2017
  • D. Katsman, M.A. Klufas, D.S. Sarraf, S.V. Sadda. Retinal arterial tortuosity in moyamoya disease. JAMA Ophthalmology. 134(1): 111-114. 2016
  • D. Katsman, E.J. Stackpole, D.R. Domin, D.B. Farber. Embryonic stem cell-derived microvesicles induce gene expression changes in Muller cells of the retina. PLoS One; 7(11): e50417. 2012
  • S, Li, J.J. Overman, D. Katsman, S.V. Kozlov, C.J. Donnelly, J.L. Twiss, R.J. Giger, G. Coppola, D.H. Geschwind, S.T. Carmichael. An age-related transcriptome provides molecular control of axonal sprouting after stroke. Nature Neuroscience; 13(12): 1496-1504. 2010
  • S.T. Carmichael, K. Tatsukawa, D. Katsman, N. Tsuyuguchi, H.I. Kornblum. Evolution of diaschisis in a focal stroke model. Stroke; 35(3): 758-63. 2004
  • D. Katsman, J. Zheng, K. Spinelli, S.T. Carmichael. Tissue microenvironments within functional cortical subdivisions adjacent to focal stroke. Journal of Cerebral Blood Flow and Metabolism; 23:997-1009. 2003

Book chapters

  • D. B. Farber and D. Katsman. Embryonic Stem Cell-Derived Microvesicles: could they be used for retina regeneration? Retinal Degenerative Diseases 2014

Patents

  • WO 2013158258A1 Ocular Therapeutics Using Embryonic Stem Cell Microvesicles.
    Inventors: S. D. Schwartz, D. B. Farber, D. Katsman. Filed: 3/2013

Doctoral dissertation

  • Activation of Retina’s Regenerative Potential By Embryonic Stem Cell-Derived Microvesicles.
    D. Katsman. 06/2012.

Select abstracts

  • A. Young, D. Katsman, D. Farber: Mouse embryonic stem cell-derived extracellular vesicles reactivate in vivo Muller progenitor cells of NMDA-damaged retinas, rescuing retinal function. ARVO (2018).
  • C. McCannel, D. Katsman, T. McCannel: Intermediate to Long Term Anti-VEGF treatment results of macular edema secondary to retinal vein occlusions. Macula Society (2016).
  • D. Katsman, D. R. Demin, D. B. Farber: Transfer of mRNA and micro-RNA by Embryonic Stem Cell-Derived Microvesicles induces gene expression changes in retinal progenitor Muller cells. ARVO (2012). Recipient of Hot Topic Notation.
  • D. Katsman, D. B. Farber: Transfer of mRNA and micro-RNA by Embryonic Stem Cell- Derived Microvesicles up-regulate early retinal progenitor genes while downregulating growth inhibitor molecules in Müller cells. ISSCR (2011).
  • D. Katsman, D. B. Farber: Transfer of mRNA and micro-RNA by Embryonic Stem Cell- Derived Microvesicles induces upregulation of progenitor genes in retinal Müller cells. UCLA Stem Cell Conference (2011).
  • D. Katsman, D. B. Farber: Selective transfer of mRNA and micro-RNA to retinal progenitor Muller cells by embryonic stem cell-derived microvesicles. Tri-institutional CIRM Retreat (2010).
  • D. Katsman, D. B. Farber: Transfer of Embryonic Stem Cell mRNA and microRNA to the Muller cells of the retina by embryonic stem cell-derived microvesicles. CIRM Grantee Meeting (2010).
  • D. Katsman, D. B. Farber: Transfer of Embryonic Stem Cell mRNA and microRNA to the Muller cells of the retina by embryonic stem cell-derived microvesicles. UCLA Stem Cell Symposium (2010).
  • K. Chong, D. Katsman, C. Hwang, H. Chang, I. Jarullazada, R. A. Goldberg: Malar festoon and mound- multiple causes, multimodality treatment. American Society for Ophthalmic Plastic and Reconstructive Surgery Meeting (2010).
  • S. Li, J. J. Overman, D. Katsman, G. Coppola, D. H. Geschwind, S. T. Carmichael: The insulin-like growth factor-1 system is associated with axonal sprouting in the somatosensory cortex of the mouse after stroke. Society for Neuroscience Meeting (2008).
  • J. Overman, A. Kwok, D. Willis, D. Katsman, S. Li, J. Ohab, J. Twiss, S. Carmichael: Post- stroke blockade of ephrinA5 increases axonal sprouting in layer IV of the mouse somatosensory cortex. Society for Neuroscience Meeting (2007).
  • D. Katsman, S. Carmichael: Genetic profiling of individual neurons in the peri-infarct penumbra after focal cortical stroke. International Society for Psychoneuroendocrinology Meeting (2006).
  • D. Katsman, S. Carmichael: A novel method of gene expression analysis of sprouting neurons after focal cortical stroke. HHMI Meeting of Medical Student Fellows (2006).
  • D. Katsman, S. Carmichael: Selective Isolation and gene expression analysis of sprouting neurons after stroke. Society for Neuroscience Meeting (2005).
  • D. Katsman, S. T. Carmichael: Selective isolation and gene expression analysis of the transcriptome of sprouting neurons after focal cortical stroke. HHMI Meeting of Medical Student Fellows (2005).
  • D. Katsman, S. T. Carmichael: Gene expression analysis of selectively isolated sprouting neurons after focal cortical stroke. 9 Repair (Taiwan, 2005). International Conference on Neural Transplantation and
  • L. Luke, J. Momiy, I Archibeque, T. Nolan, D. Katsman, S. T. Carmichael: Stroke induces reorganization and reduction of growth-inhibitory molecules during axonal sprouting. Society for Neuroscience Meeting (2004).
  • S. T. Carmichael, I. Archibeque, T. Nolan, L. Luke, S. Li, D. Katsman: Stroke induces a unique profile of neuronal growth-associated genes in the region of axonal sprouting. Society for Neuroscience Meeting (2004), Keystone Conference (2005).
  • S. T. Carmichael, I. Archibeque, D. Katsman: Axonal sprouting after stroke occurs within specific cortical circuits and involves a unique profile of growth associated proteins. Society for Neuroscience Meeting (2003), AHA Young Investigators Forum (2003).
  • S. T. Carmichael, D. Katsman, K. Tatsukawa, I. Saxe, N. Tsuyuguchi, H. Kornblum: Small cortical strokes produce transient widespread diaschisis as determined by micro-PET. Society for Neuroscience Meeting (2002).
  • S. T. Carmichael, D. Katsman, K. Tatsukawa, I. Saxe, N. Tsuyuguchi, H. Kornblum: Small cortical strokes produce transient widespread diaschisis as determined by micro-PET. Society for Neuroscience Meeting (2002).
  • D. Katsman, S. T. Carmichael: Focal cortical stroke induces reactivation of developmentally regulated proteins within areas of partial damage. Society for Neuroscience Meeting (2002).
  • K. Sinchak, M Kazeri, D. Katsman, P. E. Micevych: Sexual receptivity is associated with a reduction in internalization of mu-opioid receptors in the MPN in cycling and steroid primed ovariectomized rats. Society for Neuroscience Meeting (1999).

Selected oral presentations

  • Retinal detachment in a syphilitic patient: an unexpected masquerade syndrome. Pacific Retina Club. Los Angeles, CA, 2017
  • Panretinal degeneration associated with long-term hydroxychloroquine use and heterozygous USH2A mutation. Pacific Retina Club. Los Angeles, CA, 2016
  • Retinal arterial tortuosity in Moyamoya disease. Doheny Eye Institute Scholar Day. Los Angeles, CA, 2016
  • Malar festoon and mound- multiple causes, multimodality treatments. Jules Stein Eye Institute Annual Research Symposium. Los Angeles, CA, 2012
  • Transfer of mRNA and micro-RNA by embryonic stem cell-derived microvesicles induce a regeneration program in retinal progenitor cells.
    Association for Research in Vision and Ophthalmology. Orlando, FL, 2012
  • Transfer of mRNA and micro-RNA by embryonic stem cell-derived microvesicles induce gene expression changes in retinal progenitor Muller cells.
    International Society for Stem Cell Research. Toronto, Canada, 2011

Medical missionary work

  • 09/2015 Colorado Airlift Outreach Medical Mission, San Quintin, Baja, Mexico El Buen Pastor Hospital, Volunteer Cataract Surgeon
  • 06/2018 Latinos Unidos Fundacion, Pedro de Alvarado, Guatemala Ophthalmology